Nutritional Status of School Age Children (5-14 years) in a Rural Health Block of North India (Kashmir) Using WHO Z-Score System

Objective: To assess the nutritional status of school going children in Rural Block Hajin. Methods: School children from various primary and middle level educational facilities from a rural health block were surveyed during the School Health Program. Height and weight was measured following standard procedures. MS Excel and Interactive statistics page were used for analysis of data. Results: Both mean weight and height were higher in females than males. The overall prevalence of under nutrition was 19.2%. The prevalence of underweight was lowest in 5 year female (0.0%) and highest in 6 year male (21.5%). For Stunting 7 year males recorded the lowest (0.0%) and 12 year males the highest (28.5%) prevalence. The highest and lowest prevalence of wasting was recorded in 6 year old females (2.56%) and 9 year old males (24.6%) respectively. Prevalence of thinness was lowest in 13 year old females (14.2%) and highest in 13 year old males (47.1%).Conclusion: The nutritional status of school age children in this health block are comparatively better even though a large number of children still fall below the cutoff for various nutritional indicators

Phylogenetic analysis of human Tp53 gene using computational approach

The TP53 gene encoding p53 protein is involved in regulating a series of pathways. New discoveries about the function and control of p53 are still in progress and it is hoped to develop better therapeutics and diagnostics by exploiting this system. Evolutionary studies are of prime importance in the field of biological research since very long as provide the basis for comparative genomics. The sequence of Homo sapiens human TP53, transcript variant-1 mRNA sequence was retrieved from the NCBI in FASTAformat and was studied for its relationships and percent similarity within human and others species. Genetic variation among TP53 found in human beings and other organisms were studied in detail. Multiple sequence alignment and phylogenetic analysis of the human TP53, transcript variant-1 mRNA sequence through UPGMA was performed which showed its relationship and pattern of variations among different organisms. This study will help in modern research strategies through the manipulation of p53 as its pathways are emerging rapidly and one can predict its extensive clinical use in the near future for the human benefit worldwide.Key words: P53, tumour, cancer, phylogeny, sequence alignment

The modes adaptation function in a rectangular waveguide using an integrated taper metamaterial at microwave bandwidth

Volume 3 Issue 2 (February 2015

Measuring measurement--disturbance relationships with weak values

Using formal definitions for measurement precision {\epsilon} and disturbance (measurement backaction) {\eta}, Ozawa [Phys. Rev. A 67, 042105 (2003)] has shown that Heisenberg's claimed relation between these quantities is false in general. Here we show that the quantities introduced by Ozawa can be determined experimentally, using no prior knowledge of the measurement under investigation --- both quantities correspond to the root-mean-squared difference given by a weak-valued probability distribution. We propose a simple three-qubit experiment which would illustrate the failure of Heisenberg's measurement--disturbance relation, and the validity of an alternative relation proposed by Ozawa

The genetics of intellectual disability: advancing technology and gene editing [version 1; peer review: 2 approved]

Intellectual disability (ID) is a neurodevelopmental condition affecting 1–3% of the world’s population. Genetic factors play a key role causing the congenital limitations in intellectual functioning and adaptive behavior. The heterogeneity of ID makes it more challenging for genetic and clinical diagnosis, but the advent of large-scale genome sequencing projects in a trio approach has proven very effective. However, many variants are still difficult to interpret. A combined approach of next-generation sequencing and functional, electrophysiological, and bioinformatics analysis has identified new ways to understand the causes of ID and help to interpret novel ID-causing genes. This approach offers new targets for ID therapy and increases the efficiency of ID diagnosis. The most recent functional advancements and new gene editing techniques involving the use of CRISPR–Cas9 allow for targeted editing of DNA in in vitro and more effective mammalian and human tissue-derived disease models. The expansion of genomic analysis of ID patients in diverse and ancient populations can reveal rare novel disease-causing genes

CatSper ion channels: Bioinformatics analysis in Homo sapiens

Due to the availability of huge amount of molecular biology data, our main focus was to determine the protein structures, functions and their role in different molecular pathways. The 3-D structure prediction of protein is important in medicine and biotechnology. Molecular docking not only finds the interaction between proteins but also the accurate models of energy of these interacting proteins and helps in further designing of the better drug for that particular protein. The drug targeting is either to inhibit, restore or for the modification of the protein structure. CatSper protein family is calcium ion permeable channels, located in the plasma membrane of sperm tail. It contains a conserved domain of six transmembrane helices in their protein sequence. These four CatSper proteins (1 to 4) assemble and form tetramer, calcium selective channel. It has been found that all members of CatSper protein family (1-4) have a role in hyperactivation in sperm and fertilization processes. As a result of deletion of certain regions (bps) containing these genes along with some other genes, male infertility occurs. We have predicted and analyzed the 3D structures of all members of CatSper protein family in this article. Docking of predicted 3D structures of CatSper protein family, with calcium ion was also performed to verify their interactions.Key words: CatSper, bioinformatics analysis, infertility, cation channel

Complex joint probabilities as expressions of determinism in quantum mechanics

The density operator of a quantum state can be represented as a complex joint probability of any two observables whose eigenstates have non-zero mutual overlap. Transformations to a new basis set are then expressed in terms of complex conditional probabilities that describe the fundamental relation between precise statements about the three different observables. Since such transformations merely change the representation of the quantum state, these conditional probabilities provide a state-independent definition of the deterministic relation between the outcomes of different quantum measurements. In this paper, it is shown how classical reality emerges as an approximation to the fundamental laws of quantum determinism expressed by complex conditional probabilities. The quantum mechanical origin of phase spaces and trajectories is identified and implications for the interpretation of quantum measurements are considered. It is argued that the transformation laws of quantum determinism provide a fundamental description of the measurement dependence of empirical reality.Comment: 12 pages, including 1 figure, updated introduction includes references to the historical background of complex joint probabilities and to related work by Lars M. Johanse

A double-slit `which-way' experiment on the complementarity--uncertainty debate

A which-way measurement in Young's double-slit will destroy the interference pattern. Bohr claimed this complementarity between wave- and particle behaviour is enforced by Heisenberg's uncertainty principle: distinguishing two positions a distance s apart transfers a random momentum q \sim \hbar/s to the particle. This claim has been subject to debate: Scully et al. asserted that in some situations interference can be destroyed with no momentum transfer, while Storey et al. asserted that Bohr's stance is always valid. We address this issue using the experimental technique of weak measurement. We measure a distribution for q that spreads well beyond [-\hbar/s, \hbar/s], but nevertheless has a variance consistent with zero. This weakvalued momentum-transfer distribution P_{wv}(q) thus reflects both sides of the debate.Comment: 13 pages, 4 figure

M-Theory on Deformed Superspace

In this paper we will analyse a noncommutative deformation of the ABJM theory in N=1 superspace formalism. We will then analyse the BRST and the anti-BRST symmetries for this deformed ABJM theory, in linear as well as non-linear gauges. We will show that the sum of gauge fixing term and the ghost term for this deformed ABJM theory can be expressed as a combination of the total BRST and the total anti-BRST variation, in Landau and non-linear gauges. We will show that in Landau and Curci-Ferrari gauges this deformed ABJM theory is invariant under a additional set of symmetry transformations. We will also discuss the effect that the addition of a bare mass term has on this theory.Comment: 16 pages, 0 figures, accepted for publication in Phys Rev